HP's new encryption will protect keys from exposure even while they are in use, with the system set to be rolled out along its cloud, mobile and on-premise services.
Unveiled as part of its Discover event held in Las Vegas, the scheme uses homomorphic encryption in which keys are combined and separated as necessary, meaning that a single snapshot would not give hackers access to the data.
Art Gilliland, senior vice president of enterprise security products at HP, said: "As organisations embrace the New Style of IT, protecting sensitive information as it moves within and outside the enterprise becomes more critical than ever before."
Homomorphic encryption has been long sought after by IT security, allowing data to be used without decrypting it, with IBM being granted a patent earlier this year for technology capable of it.
HP's new technology is similarly patented, with the software firm being unable to access the master keys of its clients, an approach claimed to be unique.
The combination of many different types of enterprise software has been a challenge for companies such as HP, SAP or Salesforce, with different environments posing a range of security challenges.
HP will also be rolling out its products as a service to customers of SAP HANA, the partnership being just the latest in a flurry of collaborations between enterprise software companies.
It has also opened a network for software developers, vendors and system integrators called the HP Helion Network, which will also give its enterprise customers access to a wide array of applications.